Follicle Stimulating Hormone Receptor (FSHR)
Although the importance of follicle-stimulating hormone (FSH) in the reproduction has been well recognized for many years, FSH receptor (FSHR) had not been identified until 1970. High-affinity, low-capacity binding sites for FSH were demonstrated in 1972 using rat testicular tubules incubated with radiolabeled FSH (Simoni et al. 1997). In the following years, FSHR was identified, isolated, and purified in several species and cellular localization, ligand-receptor interaction, and intracellular signaling were studied extensively. FSHR gene was cloned in 1990 by screening rat Sertoli cell cDNA library. Since then, FSHR/Fshr has been cloned in several species ranging from human to reptile (Simoni et al. 1997). These findings led to identification of FSHR mutations and polymorphisms that either enhance (activating or gain-of-function mutation) or impair (inactivating or loss-of-function mutation) the function of the receptor (Lussiana...
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- UniProtKB/Swiss-Prot. P23945 (FSHR_HUMAN). 2016. http://www.uniprot.org/uniprot/P23945. Accessed 1 Oct 2016.