Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

CCL5

  • Carlos Eduardo Repeke
  • Thiago Pompermaier Garlet
  • Andreia Espíndola Vieira
  • Daiana Broll
  • Fernando Queiroz Cunha
  • Gustavo Pompermaier Garlet
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_580

Synonyms

 RANTES

Historical Background

CCL5 was initially described in 1988 and this new protein was named for its characteristics: Regulated upon Activation expressed by Normal T cells and presumably Secreted (RANTES) (Schall et al. 1988). A relatively new technology, at the time, was used to identify RANTES, subtraction cDNA libraries, which help to distinguish genes expressed in one cell and not in another. This genetic approach has since led to the uncovering of about 50 other chemokines, and in order to clarify the nomenclature of all chemokines and their receptors, a new nomenclature has been introduced, in which RANTES has been renamed CCL5 (Zlotnik and Yoshie 2000). CCL5 was first discovered in T cell-specific cDNA, and this initial report on CCL5 placed further attention on a new family of chemotactic proteins that proved to be important in influencing a series of biologic and pathological processes (Levy 2009).

Collectively, chemokines are defined as small (8–14 kDa) proteins...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Carlos Eduardo Repeke
    • 1
  • Thiago Pompermaier Garlet
    • 2
  • Andreia Espíndola Vieira
    • 3
  • Daiana Broll
    • 4
  • Fernando Queiroz Cunha
    • 5
  • Gustavo Pompermaier Garlet
    • 3
  1. 1.PPGCAS Lab, Department of Dentistry of LagartoFederal University of Sergipe – DOL/UFSLagartoBrazil
  2. 2.Department of Structural and Molecular Biology and GeneticsState University of Ponta GrossaPonta GrossaBrazil
  3. 3.OSTEOimmunology Lab, Department of Biological Sciences, School of Dentistry of BauruSão Paulo University, FOB/USPBauruBrazil
  4. 4.PPGCSFederal Unversity of SergipeSão CristóvãoBrazil
  5. 5.Inflammation lab, Department of Pharmacology, School of Medicine of Ribeirão PretoSão Paulo University – FMRP/USPBauruBrazil