SYX/PLEKHG5, A Rhoa Guanine Exchange Factor Involved in Cell Migration and Angiogenesis
Plekhg5 first emerged as a partial cDNA clone KIAA0720 in the HUGE (Human Unidentified Gene-Encoded) database of large proteins analyzed by the Kazusa Human cDNA Project in Japan (http://www.kazusa.or.jp/huge). It was initially characterized as a RhoA-specific GEF and a potential oncogen named GEF720 (de Toledo et al. 2003). Independently, the rat cDNA of the same protein (named Tech) was characterized also as a RhoA-specific GEF that was highly expressed in cortical and hippocampal neurons (Marx et al. 2005). Two full-length cDNA clones of the mouse ortholog were identified as splice variants (named Syx1 and Syx2) and characterized as participants in cell motility (Liu and Horowitz 2006).
Splice Variants and Domain Structure
The majority of the known splice-variants of Plekhg5 are produced by the initiation of transcription at alternate 5′ start codons (http://www.uniprot.org/uniprot/O94827). These five transcripts code for...
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