Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • João Gonçalves
  • Helena Soares
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_551


Historical Background

The major microtubule-organizing center in animal cells is the centrosome which consists of a pair of centrioles surrounded by the pericentriolar matrix. In interphase cells, centrosomes nucleate and organize the microtubule cytoskeleton and are usually maintained at the cell center in close association with the nucleus (Bettencourt-Dias and Glover 2007). This association constitutes a primordial axis of cytoplasmic compartment organization and organelle positioning (e.g., ER and Golgi apparatus). Centrosomes are also involved in mitotic spindle formation, and an aberrant centrosome number has been linked to multipolar spindles and to cancer cells. In the last years, the ability of centrosomes to become basal bodies and assemble cilia emerged also as a critical function (Bettencourt-Dias and Glover 2007). Cilia are now established as having important roles as movement generating and sensory organelles being essential for...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • João Gonçalves
    • 1
    • 2
  • Helena Soares
    • 3
    • 4
  1. 1.Centro de Química e Bioquímica, Faculdade de CiênciasUniversidade de LisboaLisboaPortugal
  2. 2.Lunenfeld-Tanenbaum Research InstituteTorontoCanada
  3. 3.Departamento de Química e BioquímicaCentro de Química e Bioquímica, Faculdade de Ciências, Universidade de LisboaLisboaPortugal
  4. 4.Escola Superior de Tecnologia da Saúde de LisboaLisboaPortugal