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Encyclopedia of Signaling Molecules pp 3310–3314Cite as

Myosin III

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Synonyms

LpMYO3; MYO3A; MYO3B; myoIIILim; NINAC (p174, p132)

Historical Background

Class III myosins are one of many classes of myosin motor proteins. The first class III myosin, ninaC (neither inactivation nor afterpotential C), was identified in Drosophila as a gene responsible for abnormal phototransduction (Montell and Rubin 1988). This novel class of myosin is unique in having an N-terminal putative kinase domain joined to a myosin motor domain. The second class III myosin was isolated from the horseshoe crab Limulus polyphemus as a phosphoprotein regulated by a circadian clock; it is exclusively expressed in photoreceptors (Battelle et al. 1998). Subsequently, human class III myosin, MYO3A, was isolated by degenerated polymerase chain reaction (PCR) and rapid amplification of cDNA ends PCR from retina and a retinal pigment epithelial cell line (Dose and Burnside 2000). A shorter class III isoform, MYO3B, encoded by a different gene from MYO3A, was also identified (Dose and...

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References

  • Battelle BA, Andrews AW, Calman BG, Sellers JR, Greenberg RM, Smith WC. A myosin III from Limulus eyes is a clock-regulated phosphoprotein. J Neurosci. 1998;18(12):4548–59.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cronin MA, Diao F, Tsunoda S. Light-dependent subcellular translocation of Gqalpha in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC. J Cell Sci. 2004;117(Pt 20):4797–806.

    Article  CAS  PubMed  Google Scholar 

  • Dose AC, Burnside B. Cloning and chromosomal localization of a human class III myosin. Genomics. 2000;67(3):333–42.

    Article  CAS  PubMed  Google Scholar 

  • Dose AC, Burnside B. A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome. Genomics. 2002;79(5):621–4.

    Article  CAS  PubMed  Google Scholar 

  • Dose AC, Hillman DW, Wong C, Sohlberg L, Lin-Jones J, Burnside B. Myo3A, one of two class III myosin genes expressed in vertebrate retina, is localized to the calycal processes of rod and cone photoreceptors and is expressed in the sacculus. Mol Biol Cell. 2003;14(3):1058–73.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dose AC, Ananthanarayanan S, Moore JE, Corsa AC, Burnside B, Yengo CM. The kinase domain alters the kinetic properties of the myosin IIIA motor. Biochemistry. 2008;47(8):2485–96.

    Article  CAS  PubMed  Google Scholar 

  • Erickson FL, Corsa AC, Dose AC, Burnside B. Localization of a class III myosin to filopodia tips in transfected HeLa cells requires an actin-binding site in its tail domain. Mol Biol Cell. 2003;14(10):4173–80.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hicks JL, Liu X, Williams DS. Role of the ninaC proteins in photoreceptor cell structure: ultrastructure of ninaC deletion mutants and binding to actin filaments. Cell Motil Cytoskeleton. 1996;35(4):367–79.

    Article  CAS  PubMed  Google Scholar 

  • Kambara T, Komaba S, Ikebe M. Human myosin III is a motor having an extremely high affinity for actin. J Biol Chem. 2006;281(49):37291–301.

    Article  CAS  PubMed  Google Scholar 

  • Kempler K, Toth J, Yamashita R, Mapel G, Robinson K, Cardasis H, et al. Loop 2 of limulus myosin III is phosphorylated by protein kinase A and autophosphorylation. Biochemistry. 2007;46(14):4280–93.

    Article  PubMed  CAS  Google Scholar 

  • Komaba S, Inoue A, Maruta S, Hosoya H, Ikebe M. Determination of human myosin III as a motor protein having a protein kinase activity. J Biol Chem. 2003;278(24):21352–60.

    Article  CAS  PubMed  Google Scholar 

  • Komaba S, Watanabe S, Umeki N, Sato O, Ikebe M. Effect of phosphorylation in the motor domain of human myosin IIIA on its ATP hydrolysis cycle. Biochemistry. 2009;49(17):3695–702.

    Article  CAS  Google Scholar 

  • Lee SJ, Montell C. Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron. 2004;43(1):95–103.

    Article  CAS  PubMed  Google Scholar 

  • Li HS, Porter JA, Montell C. Requirement for the NINAC kinase/myosin for stable termination of the visual cascade. J Neurosci. 1998;18(23):9601–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lin-Jones J, Parker E, Wu M, Dose A, Burnside B. Myosin 3A transgene expression produces abnormal actin filament bundles in transgenic Xenopus laevis rod photoreceptors. J Cell Sci. 2004;117(Pt 24):5825–34.

    Article  CAS  PubMed  Google Scholar 

  • Meyer NE, Joel-Almagor T, Frechter S, Minke B, Huber A. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. J Cell Sci. 2006;119(Pt 12):2592–603.

    Article  PubMed  CAS  Google Scholar 

  • Montell C, Rubin GM. The Drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head. Cell. 1988;52(5):757–72.

    Article  CAS  PubMed  Google Scholar 

  • Ng KP, Kambara T, Matsuura M, Burke M, Ikebe M. Identification of myosin III as a protein kinase. Biochemistry. 1996;35(29):9392–9.

    Article  CAS  PubMed  Google Scholar 

  • Porter JA, Montell C. Distinct roles of the Drosophila ninaC kinase and myosin domains revealed by systematic mutagenesis. J Cell Biol. 1993;122(3):601–12.

    Article  CAS  PubMed  Google Scholar 

  • Porter JA, Hicks JL, Williams DS, Montell C. Differential localizations of and requirements for the two Drosophila ninaC kinase/myosins in photoreceptor cells. J Cell Biol. 1992;116(3):683–93.

    Article  CAS  PubMed  Google Scholar 

  • Porter JA, Yu M, Doberstein SK, Pollard TD, Montell C. Dependence of calmodulin localization in the retina on the NINAC unconventional myosin. Science. 1993;262(5136):1038–42.

    Article  CAS  PubMed  Google Scholar 

  • Salles FT, Merritt Jr RC, Manor U, Dougherty GW, Sousa AD, Moore JE, et al. Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments. Nat Cell Biol. 2009;11(4):443–50.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Satoh AK, Ready DF. Arrestin1 mediates light-dependent rhodopsin endocytosis and cell survival. Curr Biol. 2005;15(19):1722–33.

    Article  CAS  PubMed  Google Scholar 

  • Schneider ME, Dose AC, Salles FT, Chang W, Erickson FL, Burnside B, et al. A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression. J Neurosci. 2006;26(40):10243–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Walsh T, Walsh V, Vreugde S, Hertzano R, Shahin H, Haika S, et al. From flies’ eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proc Natl Acad Sci U S A. 2002;99(11):7518–23.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wes PD, XZ X, Li HS, Chien F, Doberstein SK, Montell C. Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD. Nat Neurosci. 1999;2(5):447–53.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Boston Biomedical Research Institute, 64 Grove St, Watertown, MA, 02472-2829, USA

    Shigeru Komaba

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  1. Shigeru Komaba
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Correspondence to Shigeru Komaba .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Komaba, S. (2018). Myosin III. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_541

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