Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Myosin III

  • Shigeru Komaba
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_541

Synonyms

Historical Background

Class III myosins are one of many classes of  myosin motor proteins. The first class III myosin, ninaC (neither inactivation nor afterpotential C), was identified in Drosophila as a gene responsible for abnormal phototransduction (Montell and Rubin 1988). This novel class of myosin is unique in having an N-terminal putative kinase domain joined to a myosin motor domain. The second class III myosin was isolated from the horseshoe crab Limulus polyphemus as a phosphoprotein regulated by a circadian clock; it is exclusively expressed in photoreceptors (Battelle et al. 1998). Subsequently, human class III myosin, MYO3A, was isolated by degenerated polymerase chain reaction (PCR) and rapid amplification of cDNA ends PCR from retina and a retinal pigment epithelial cell line (Dose and Burnside 2000). A shorter class III isoform, MYO3B, encoded by a different gene from MYO3A, was also identified (Dose and...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Boston Biomedical Research InstituteWatertownUSA