Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Nrf2 (NF-E2-Related Factor2)

  • Sang Geon KimEmail author
  • Woo Hyung Lee
  • Young Woo Kim
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_540


Historical Background

Nrf2 was found as a member of nuclear factor erythroid 2 (NF-E2) transcription factor family in 1994 (Moi et al. 1994). Nrf2 is a basic Leucine Zipper (bZIP) transcription factor that belongs to the Cap’n’Collar (CNC) family (p45-NFE2, Nrf1, Nrf2, and Nrf3) and is expressed ubiquitously in various tissues (Moi et al. 1994). Yamamoto and his colleagues showed that Nrf2 forms a heterodimer with small Mafs and induces phase-II detoxifying enzymes through antioxidant response elements (AREs) in the promoter regions of the target genes (Tong et al. 2006). A myriad of studies have identified Nrf2 as a sensor that acts against oxidative stress or electrophilic chemicals. In spite of the similarity in nucleotide sequences between Nrf2 and NF-E2, it was not involved in erythropoiesis and development in a murine model.

Oxidative stress is featured by high levels of reactive oxygen species (ROS), which exerts a harmful effect...

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This work was supported by the National Research Foundation of Korea grant funded by the Korea government (MEST) (No. 2009-0063233) and the World Class University project (which is also funded by Korea government) (R32-2008-000-10098-0).


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sang Geon Kim
    • 1
    Email author
  • Woo Hyung Lee
    • 1
  • Young Woo Kim
    • 1
  1. 1.College of PharmacySeoul National UniversitySeoulKorea