c-Src Family of Tyrosine Kinases
In 1911, pathologist Francis Peyton Rous isolated a virus from a Plymouth Rock chicken that has continued to bear his name, the Rous sarcoma virus (RSV) (Rous 1911). Rous sarcoma virus is the archetypal retrovirus, capable of causing tumors in chickens and rapidly transforming cells in culture with high efficiency through production of the protein viral sarcoma (v-Src), the first identified transforming protein. In 1976, Bishop and Varmus demonstrated that the v-Src gene has a normal cellular homolog gene (protooncogene), c-Src, and that the v-Src gene product, pp60v-Src or v-Src, is a phosphoprotein with an apparent molecular mass of 60 kDa with intrinsic protein kinase activity (Stehelin et al. 1976). Sequencing of the chicken c-Src gene and the RSV v-Src gene demonstrated that the two genes are closely related except at the C-terminal end, and it is this structural difference that leads to constitutive activation of v-Src...
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