Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Mapkap Kinase 2/3 (MK2/3)

  • Matthias GaestelEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_531


Historical Background

Formally, all protein kinases downstream to MAP kinases should be regarded as MAPK-activated protein kinases (MKs). This would include ribosomal S6-kinases (RSKs); mitogen- and stress-activated protein kinases (MSKs); MAP kinase-interacting kinases (MNKs); as well as MK2, MK3, and MK5/PRAK (Roux and Blenis 2004). However, due to the specificity of activation, this group of protein kinases is further subdivided (Fig. 1): RSKs are activated by classical ERKs (Erk1/Erk2) and MSKs and MNKs are phosphorylated by both ERKs and p38 MAPK. MK2 and MK3 are the only MKs which are exclusively activated by p38 MAPK. MK5/PRAK has been described as a “p38-regulated and -activated kinase (PRAK),” but its activation by p38 MAPK is challenged, and alternative activation by atypical MAPKs (Erk3/Erk4) is discussed (Gaestel 2006). For historical reasons RSK was designated MAPKAPK 1...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Hannover Medical SchoolInstitute of Cell BiochemistryHannoverGermany