Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Androgen Receptor (AR)

  • Hatice Zeynep Nenseth
  • Martina Tesikova
  • Fahri SaatciogluEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_514


Historical Background

Androgen receptor (AR) mediates the effects of androgens that are responsible for diverse biological functions, such as development and maintenance of the male reproductive system, as well as involvement in disease states, such as prostate cancer (PCa) (for a review, see Brinkmann (2011)). AR is a ligand-activated transcription factor (TF) that belongs to the steroid hormone receptor (SHR) family within the nuclear receptor (NR) superfamily of TFs (for a review, see Huang et al. (2010)). In addition to AR, the SHR family contains the glucocorticoid receptor (GR), mineralocorticoid receptor (MR), progesterone receptor (PR), and the estrogen receptor (ER). SHRs are structurally and functionally related and mediate the action of steroid hormones that affect nearly all aspects of development and homeostasis; they are also implicated in a number of...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Hatice Zeynep Nenseth
    • 1
  • Martina Tesikova
    • 1
  • Fahri Saatcioglu
    • 1
    • 2
    Email author
  1. 1.Department of BiosciencesUniversity of OsloOsloNorway
  2. 2.Institute for Cancer Genetics and InformaticsOslo University HospitalOsloNorway