Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MTUS1/ATIP

  • Simon N. S. Louis
  • Naghmeh Varghayee
  • Laurie T. C. Chow
  • William J. Louis
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_497

Synonyms

Historical Background

Following its initial identification in Japan in 1999 (Nagase et al. 1999), mitochondrial tumor suppressor 1 (MTUS1/ATIP) (2011), a putative tumor suppressor gene, has been independently identified by research groups from Japan (Kinjo et al. 2000), Germany (Seibold et al. 2003; Wruck et al. 2005), and France (Nouet et al. 2004). As a result, MTUS1/ATIP has been designated a variety of different names; therefore, the nomenclature used to describe MTUS1/ATIP in publications can be confusing.

MTUS1/ATIP was first identified in 1999 following the sequencing of 100 cDNA clones of unknown human genes from two sets of size-fractionated human adult and fetal brain cDNA libraries (Nagase et al. 1999). At this time, it...

This is a preview of subscription content, log in to check access.

References

  1. Chanrion M, Negre V, Fontaine H, Salvetat N, Bibeau F, Mac Grogan G, Mauriac L, Katsaros D, Molina F, Theillet C, Darbon JM. A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer. Clin Cancer Res. 2008;14(6):1744–52.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Chow L, Rezmann L, Immamura K, Wang L, Catt K, Tikellis C, Louis WJ, Frauman AG, Louis SNS. Functional angiotensin II type 2 receptors inhibit growth factor signalling in LNCaP and PC3 prostate cancer cell lines. Prostate. 2008;68(6):651–60.CrossRefPubMedGoogle Scholar
  3. Di Benedetto M, Bieche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C. Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP. Gene. 2006a;380(2):127–36.CrossRefPubMedGoogle Scholar
  4. Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C. Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. Mol Cell Endocrinol. 2006b;252(1–2):207–15.CrossRefPubMedGoogle Scholar
  5. Ding X, Zhang N, Cai Y, Li S, Zheng C, Jin Y, Yu T, Wang A, Zhou X. Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma. Mol Oncol. 2012;6(1):73–80.CrossRefPubMedGoogle Scholar
  6. Elbaz N, Bedecs K, Masson M, Sutren M, Strosberg AD, Nahmias C. Functional trans-inactivation of insulin receptor kinase by growth-inhibitory angiotensin II AT2 receptor. Mol Endocrinol. 2000;14(6):795–804.CrossRefPubMedGoogle Scholar
  7. Frank B, Bermejo JL, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, Kiechle M, Bugert P, Schmutzler RK, Bartram CR, Burwinkel B. Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk. Carcinogenesis. 2007;28(7):1442–5.CrossRefPubMedGoogle Scholar
  8. Hinds DA, Kloek AP, Jen M, Chen X, Frazer KA. Common deletions and SNPs are in linkage disequilibrium in the human genome. Nat Genet. 2006;38(1):82–5.CrossRefPubMedGoogle Scholar
  9. Hinkelbein J, Böhm L, Spelten O, Sander D, Soltész S, Braunecker S. Hyperoxia-induced protein alterations in renal rat tissue: a quantitative proteomic approach to identify hyperoxia-induced effects in cellular signaling pathways. Dis Markers. 2015;2015: 12 pp. Article ID:964263. doi:10.1155/2015/964263CrossRefGoogle Scholar
  10. Jing F, Mogi M, Min L-J, Ohshima K, Nakaoka H, Tsukuda K, Wang X, Iwanami J, Horiuchi M. Effect of angiotensin II type 2 receptor-interacting protein on adipose tissue function via modulation of macrophage polarization. PLoS One. 2013;8(4):e60067.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Kinjo T, Isomura M, Iwamasa T, Nakamura Y. Molecular cloning and characterization of two novel genes on chromosome 8p21.3. J Hum Genet. 2000;45(1):12–7.CrossRefPubMedGoogle Scholar
  12. Krezel MA, Rezmann LA, Varghayee N, Pete J, Frauman AG, Louis SN. Gene sequencing and tissue expression of unknown isoforms of an angiotensin II type 2 receptor interacting protein, ATIP, in the rat. Biosci Biotechnol Biochem. 2011;75(3):414–8.CrossRefPubMedGoogle Scholar
  13. Li JM, Mogi M, Tsukuda K, Tomochika H, Iwanami J, Min LJ, Nahmias C, Iwai M, Horiuchi M. Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. Mol Endocrinol. 2007;21(2):499–511.CrossRefGoogle Scholar
  14. Louis SN, Wang L, Chow L, Rezmann LA, Imamura K, MacGregor DP, Casely D, Catt KJ, Frauman AG, Louis WJ. Appearance of angiotensin II expression in non-basal epithelial cells is an early feature of malignant change in human prostate. Cancer Detect Prev. 2007;31(5):391–5.CrossRefPubMedGoogle Scholar
  15. Louis SN, Chow L, Rezmann L, Krezel MA, Catt KJ, Tikellis C, Frauman AG, Louis WJ. Expression and function of ATIP/MTUS1 in human prostate cancer cell lines. Prostate. 2010;70(14):1563–74.CrossRefPubMedGoogle Scholar
  16. Louis SNS, Chow LTC, Varghayee N, Rezmann LA, Frauman AG, Louis WJ. The expression of MTUS1/ATIP and its major isoforms, ATIP1 and ATIP3, in human prostate cancer. Cancer. 2011;3(4):3824–57.CrossRefGoogle Scholar
  17. Mahjabeen I, Kayani MA. Loss of mitochondrial tumor suppressor genes expression is associated with unfavorable clinical outcome in head and neck squamous cell carcinoma: data from retrospective study. PLoS One. 2016;11(1):e0146948.PubMedPubMedCentralCrossRefGoogle Scholar
  18. Molina A, Velot L, Ghouinem L, Abdelkarim M, Bouchet BP, Luissint AC, Bouhlel I, Morel M, Sapharikas E, Di Tommaso A, Honoré S, Braguer D, Gruel N, Vincent-Salomon A, Delattre O, Sigal-Zafrani B, André F, Terris B, Akhmanova A, Di Benedetto M, Nahmias C, Rodrigues-Ferreira S. ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics. Cancer Res. 2013;73(9):2905–15.CrossRefPubMedGoogle Scholar
  19. MTUS1 microtubule associated tumor suppressor 1 (Homo sapiens) (database on the Internet). NCBI National Center for Biotechnology Information (cited updated on 7 Aug 2011). Available from: http://www.ncbi.nlm.nih.gov/gene/57509
  20. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999;6(5):337–45.CrossRefPubMedGoogle Scholar
  21. Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J Biol Chem. 2004;279(28):28989–97.CrossRefPubMedGoogle Scholar
  22. Pils D, Horak P, Gleiss A, Sax C, Fabjani G, Moebus VJ, Zielinski C, Reinthaller A, Zeillinger R, Krainer M. Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival. Cancer. 2005;104(11):2417–29.CrossRefPubMedGoogle Scholar
  23. Reinemund J, Seidel K, Steckelings UM, Zaade D, Klare S, Rompe F, Katerbaum M, Schacherl J, Li Y, Menk M, Schefe JH, Goldin-Lang P, Szabo C, Olah G, Unger T, Funke-Kaiser H. Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes. Biochem Pharmacol. 2009;77(12):1795–805.CrossRefPubMedGoogle Scholar
  24. Rodrigues-Ferreira S, Di Tommaso A, Dimitrov A, Cazaubon S, Gruel N, Colasson H, Nicolas A, Chaverot N, Molinie V, Reyal F, Sigal-Zafrani B, Terris B, Delattre O, Radvanyi F, Perez F, Vincent-Salomon A, Nahmias C. 8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis. PLoS One. 2009;4(10):e7239.PubMedPubMedCentralCrossRefGoogle Scholar
  25. Rogler A, Hoja S, Giedl J, Ekici AB, Wach S, Taubert H, Goebell PJ, Wullich B, Stöckle M, Lehmann J, Petsch S, Hartmann A, Stoehr R. Loss of MTUS1/ATIP expression is associated with adverse outcome in advanced bladder carcinomas: data from a retrospective study. BMC Cancer. 2014;14:214.PubMedPubMedCentralCrossRefGoogle Scholar
  26. Seibold S, Rudroff C, Weber M, Galle J, Wanner C, Marx M. Identification of a new tumor suppressor gene located at chromosome 8p21.3–22. FASEB J. 2003;17(9):1180–2.CrossRefPubMedGoogle Scholar
  27. Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015;21(4):389–94.PubMedPubMedCentralCrossRefGoogle Scholar
  28. Varghayee N, Krezel MA, Rezmann L, Chow L, Frauman AG, Louis WJ, Louis SN. Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2. J Renin Angiotensin Aldosterone Syst. 2015;16(1):79–91 .Epub 2013CrossRefPubMedGoogle Scholar
  29. Velot L, Molina A, Rodrigues-Ferreira S, Nehlig A, Bouchet BP, Morel M, Leconte L, Serre L, Arnal I, Braguer D, Savina A, Honore S, Nahmias C. Negative regulation of EB1 turnover at microtubule plus ends by interaction with microtubule-associated protein ATIP3. Oncotarget. 2015;6(41):43557–70.PubMedPubMedCentralCrossRefGoogle Scholar
  30. Wruck CJ, Funke-Kaiser H, Pufe T, Kusserow H, Menk M, Schefe JH, Kruse ML, Stoll M, Unger T. Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein. Arterioscler Thromb Vasc Biol. 2005;25(1):57–64.PubMedGoogle Scholar
  31. Xiao J, Chen JX, Zhu YP, Zhou LY, Shu QA, Chen LW. Reduced expression of MTUS1 mRNA is correlated with poor prognosis in bladder cancer. Oncol Lett. 2012;4(1):113–8.PubMedPubMedCentralCrossRefGoogle Scholar
  32. Zhao T, Ding X, Chang B, Zhou X, Wang A. MTUS1/ATIP3a down-regulation is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma. BMC Cancer. 2015;15:203.PubMedPubMedCentralCrossRefGoogle Scholar
  33. Zhao T, He Q, Liu Z, Ding X, Zhou X, Wang A. Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway. Oncol Lett. 2016;11(1):340–4.CrossRefPubMedGoogle Scholar
  34. Zuern C, Heimrich J, Kaufmann R, Richter KK, Settmacher U, Wanner C, Galle J, Seibold S. Down-regulation of MTUS1 in human colon tumors. Oncol Rep. 2010;23(1):183–9.PubMedGoogle Scholar
  35. Zuern C, Krenacs L, Starke S, Heimrich J, Palmetshofer A, Holtmann B, Sendtner M, Fischer T, Galle J, Wanner C, Seibold S. Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease. Int J Oncol. 2012;40(4):1079–88.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Simon N. S. Louis
    • 1
  • Naghmeh Varghayee
    • 1
  • Laurie T. C. Chow
    • 1
  • William J. Louis
    • 1
  1. 1.Clinical Pharmacology Unit, Department of Medicine Austin Health/Northern HealthUniversity of MelbourneHeidelbergAustralia