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GALR, Galanin Receptor

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References

  • Anselmi L, Stella Jr SL, Lakhter A, Hirano A, Tonini M, Sternini C. Galanin receptors in the rat gastrointestinal tract. Neuropeptides. 2005;39:349–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Borroto-Escuela DO, Narvaez M, Marcellino D, Parrado C, Narvaez JA, Tarakanov AO, Agnati LF, Díaz-Cabiale Z, Fuxe K. Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization. Biochem Biophys Res Commun. 2010;393:767–72.

    Article  PubMed  CAS  Google Scholar 

  • Branchek TA, Smith KE, Gerald C, Walker MW. Galanin receptor subtypes. Trends Pharmacol Sci. 2000;21:109–17.

    Article  PubMed  CAS  Google Scholar 

  • Fetissov SO, Jacoby AS, Brumovsky PR, Shine J, Iismaa TP, Hokfelt T. Altered hippocampal expression of neuropeptides in seizure-prone GALR1 knockout mice. Epilepsia. 2003;44:1022–33.

    Article  PubMed  CAS  Google Scholar 

  • Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux JF. Molecular cloning of a functional human galanin receptor. Proc Natl Acad Sci U S A. 1994;91:9780–3.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Howard AD, Tan C, Shiao LL, Palyha OC, McKee KK, Weinberg DH, Feighner SD, Cascieri MA, Smith RG, Van Der Ploeg LH, Sullivan KA. Molecular cloning and characterization of a new receptor for galanin. FEBS Lett. 1997;405:285–90.

    Article  PubMed  CAS  Google Scholar 

  • Kanazawa T, Misawa K, Carey TE. Galanin receptor subtypes 1 and 2 as therapeutic targets in head and neck squamous cell carcinoma. Expert Opin Ther Targets. 2010;14:289–302.

    Article  PubMed  CAS  Google Scholar 

  • Lang R, Gundlach AL, Kofler B. The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol Ther. 2007;115:177–207.

    Article  PubMed  CAS  Google Scholar 

  • Leibowitz SF. Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis. Neuropeptides. 2005;39:327–32.

    Article  PubMed  CAS  Google Scholar 

  • Liu Z, Xu Y, Wu L, Zhang S. Evolution of galanin receptor genes: insights from the deuterostome genomes. J Biomol Struct Dyn. 2010;28:97–106.

    Article  PubMed  CAS  Google Scholar 

  • Lu X, Barr AM, Kinney JW, Sanna P, Conti B, Behrens MM, Bartfai T. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc Natl Acad Sci U S A. 2005;102:874–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lu X, Ross B, Sanchez-Alavez M, Zorrilla EP, Bartfai T. Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests. Neuropeptides. 2008;42:387–97.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mitsukawa K, Lu X, Bartfai T. Galanin, galanin receptors and drug targets. Cell Mol Life Sci. 2008;65:1796–805.

    Article  PubMed  CAS  Google Scholar 

  • O’Meara G, Coumis U, Ma SY, Kehr J, Mahoney S, Bacon A, Allen SJ, Holmes F, Kahl U, Wang FH, Kearns IR, Ove-Ogren S, Dawbarn D, Mufson EJ, Davies C, Dawson G, Wynick D. Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A. 2000;97:11569–74.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ogren SO, Kehr J, Schött PA. Effects of ventral hippocampal galanin on spatial learning and on in vivo acetylcholine release in the rat. Neuroscience. 1996;75:1127–40.

    Article  PubMed  CAS  Google Scholar 

  • Rustay NR, Wrenn CC, Kinney JW, Holmes A, Bailey KR, Sullivan TL, Harris AP, Long KC, Saavedra MC, Starosta G, Innerfield CE, Yang RJ, Dreiling JL, Crawley JN. Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout mice. Neuropeptides. 2005;39:239–43.

    Article  PubMed  CAS  Google Scholar 

  • Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A. 2002;99:7136–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tatemoto K, Rökaeus Ã…, Jornvall H, McDonald TJ, Mutt V. Galanin- a novel biologically active peptide from porcine intestine. FEBS Lett. 1983;164:124–8.

    Article  PubMed  CAS  Google Scholar 

  • Wiesenfeld-Hallin Z, Xu XJ. Neuropeptides in neuropathic and inflammatory pain with special emphasis on cholecystokinin and galanin. Eur J Pharmacol. 2001;429:49–59.

    Article  PubMed  CAS  Google Scholar 

  • Zorrilla EP, Brennan M, Sabino V, Lu X, Bartfai T. Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge. Physiol Behav. 2007;91:479–85.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgments

This work was supported by Program for New Century Excellent Talents in University to Zhenhui Liu (No. NCET-08-0501), the Ministry of Science and Technology (MOST) of China (No.2008AA092603 and 2008AA09Z409) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (No. 2009–1001).

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Correspondence to Zhenhui Liu .

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Liu, Z., Li, L., Zhang, M. (2018). GALR, Galanin Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_462

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