Protein prenylation is a posttranslational modification of proteins involving the addition of isoprenyl lipids (Tamanoi and Sigman 2001). It is a post-translational modification that occurs in the cytosol and is essential for the proper localization and functions of many proteins. There are three kinds of prenyltransferases: protein farnesyltransferase (FTase), protein geranylgeranyltransferase-I (GGTase-I), and Rab geranylgeranyltransferase (RabGGTase). No additional prenyltransferases have been described to date. Farnesyltransferase (FTase) catalyzes the addition of a 15-carbon farnesyl group to proteins such as Ras proteins, Rheb proteins, nuclear lamins, and Hdj2 that end with the Cys-A1-A2-X (CA1A2X)motif, where A is an aliphatic amino acid and X is usually serine, methionine, glutamine or alanine. The lipid is covalently attached to the Cys via a thioether linkage between C1 of the farnesyl...
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