Historical Background
FRS2 stands for fibroblast growth factor (FGF) receptor substrate 2. The FGF receptor substrate 1 is phospholipase (PLC) γ, which was identified as the first substrate of FGF receptor tyrosine kinases (Gotoh et al. 2004). Historically, SNT was identified as a protein that is tyrosine phosphorylated in response to nerve growth factor (NGF) or FGF in PC12 cells and can bind to p13suc1, a yeast cyclin–dependent kinase binding protein, immobilized on agarose (Rabin et al. 1993). It was reported that there is a good correlation between the tyrosine phosphorylation of SNT and differentiation of PC12 cells. Then FRS2 was purified and cloned as a novel protein that is tyrosine phosphorylated in NIH3T3 cells in response to FGF (Kouhara et al. 1997). It turned out to be the same protein as SNT. Another protein that has...
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Gotoh, N. (2018). FRS2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_356
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DOI: https://doi.org/10.1007/978-3-319-67199-4_356
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