Reference work entry
The Rho family of small molecular weight GTP-binding proteins, which comprises 22 proteins including RhoA, Rac1, and Cdc42, was originally isolated based on their high degree of homology with the Ras proto-oncogenes (Rho = Ras homologue). Following their identification, a variety of approaches were used to isolate interacting proteins that might convey signals downstream to regulate numerous biological processes. One approach was to use GTP-loaded RhoA as a high-affinity reagent to fish for interacting proteins, and the ROCK kinases were identified in this way (Leung et al. 1995; Ishizaki et al. 1996; Matsui et al. 1996). A number of different names have been used to describe the two kinases, and early reports were sometimes not careful to accurately specify which isoforms...
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