Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

PTPN6

  • Marina Tiemi Shio
  • Martin Olivier
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_309

Synonyms

Historical Background

The Src homology region 2 (SH) domain-containing protein tyrosine phosphatase-1 (SHP-1) is a member of the large family of protein tyrosine phosphatase (PTP). SHP-1 was identified in hematopoietic cells and organs involved in immune responses such as the spleen, thymus, lymph node, and bone marrow. SHP-1 is also known as hematopoietic cell phosphatase (HCP) because of its expression in these cells. Herein the nomenclature SHP-1 will be used. Back to the beginning of the 1990s, the study of tyrosine kinases was very well advanced; however, knowledge about their natural counterpart the tyrosine phosphatases was still greatly unraveled. Early on, different research groups isolated and identified a protein that...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Health Science programUniversidade Santo Amaro, programa de Ciência da SaúdeSão PauloBrazil
  2. 2.Infectious Diseases and Immunity in Global Health (IDIGH) ProgramResearch Institute of McGill University Health CentreMontrealCanada