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Encyclopedia of Signaling Molecules pp 4337–4342Cite as

R7BP/R9AP

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Synonyms

R7 Binding Protein (R7BP); RGS9 Anchor Protein (R9AP)

Introduction and Historical Background

Regulator of G protein signaling (RGS) proteins constitute a diverse family with more than 30 members that contain the hallmark RGS domain. Most members serve as negative regulators of G protein signaling by catalyzing the GTP hydrolysis on Gα subunits leading to their inactivation (Ross and Wilkie 2000; Hollinger and Hepler 2002). Based on their structural organization and sequence homology RGS proteins are divided into five to six families (Ross and Wilkie 2000; Hollinger and Hepler 2002). The R7 RGS family (R7 RGS) contains multidomain proteins conserved from C. elegans to humans that, in mammals are represented by four members: RGS6, RGS7, RGS9, and RGS11. R7 RGS proteins play important roles in the nervous system by controlling neurotransmitter action at rhodopsin, μ-opioid, D2 dopamine, and GABA(B) receptors (Anderson et al. 2009a).

The unique feature of this group is that they...

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References

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Author information

Authors and Affiliations

  1. Department of Neuroscience, The Scripps Research Institute, 130 Scripps Way C347, Jupiter, FL, 33458, USA

    Kirill A. Martemyanov

  2. Department of Pharmacology, University of Minnesota, Minneapolis, 321 Church St. SE, Minneapolis, MN, 55455, USA

    Pooja Parameswaran

Authors
  1. Kirill A. Martemyanov
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  2. Pooja Parameswaran
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Corresponding author

Correspondence to Kirill A. Martemyanov .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Martemyanov, K.A., Parameswaran, P. (2018). R7BP/R9AP. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_259

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