Integrin α2 (ITGA2)
The integrin family of cellular receptors contains 24 α/β heterodimers that mediate adhesion to extracellular matrix (ECM), plasma proteins, or counter receptors on other cells. The cytoplasmic domains of integrin α and β subunits are linked to cytoskeleton and cellular signaling pathways. Integrin α2 subunit forms a heterodimer with integrin β1 subunit and acts as a cellular collagen receptor. Before this receptor was realized to be a member of the integrin family, the α2 subunit had already been named as the α subunit of T lymphocyte very late activation antigen 2 (VLA-2), platelet collagen receptor (glycoprotein Ia), and the larger subunit of collagen-binding extracellular matrix receptor II. Integrin α2β1 forms together with three other heterodimers, namely, α1β1, α10β1, and α11β1, the collagen receptor subfamily of the integrins...