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Encyclopedia of Signaling Molecules pp 328–333Cite as

ANT

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Synonyms

Adenine nucleotide translocase; ADP/ATP carrier

Historical Background

The adenine nucleotide translocase (ANT) or ADP/ATP carrier belongs to the evolutionarily conserved family of mitochondrial carriers (for a recent review, see Palmieri 2014). ANT constitutes one of the most abundant proteins of the mitochondrial inner membrane (IM), in which it is inserted via six transmembrane helices. Both the C- and N-termini of ANT face the mitochondrial matrix. ANT was first characterized as an antiporter that mediates the export of ATP from the mitochondrial matrix to the intermembrane space together with the import of ADP from the intermembrane space to the matrix (Pfaff and Klingenberg 1968) (Fig. 1a). Its antiporter activity is electrogenic, as it drives the stoichiometric exchange of ATP4− and ADP3−. ANT may also act as an IM channel, playing a critical role in the permeabilization of mitochondrial membranes that accompanies regulated cell death, that is, intrinsic apoptosis as...

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Authors and Affiliations

  1. UMR-S 1180, INSERM, Université Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France, Châtenay-Malabry, 92290, France

    Grégory Tufo & Catherine Brenner

  2. UMR1138, INSERM, de Recherche des Cordeliers, Centre, Paris, France

    Lorenzo Galluzzi

  3. Metabolomics Platform, Institut Gustave Roussy, Villejuif, France

    Lorenzo Galluzzi

  4. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-, HP, Paris, France

    Lorenzo Galluzzi

  5. Université Paris René Descartes, Paris, France

    Lorenzo Galluzzi

  6. Equipe Labellisée Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France

    Guido Kroemer

  7. Institut National de la Santé et de la Recherche Médicale (INSERM) U1138, Paris, France

    Guido Kroemer

  8. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France

    Guido Kroemer

  9. Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Guido Kroemer

  10. Université Pierre et Marie Curie, Paris, France

    Guido Kroemer

  11. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France

    Guido Kroemer

  12. Department of Women’s and Children’s Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Guido Kroemer

Authors
  1. Grégory Tufo
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  2. Lorenzo Galluzzi
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  3. Guido Kroemer
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  4. Catherine Brenner
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Corresponding author

Correspondence to Catherine Brenner .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Tufo, G., Galluzzi, L., Kroemer, G., Brenner, C. (2018). ANT. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_175

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