Rin (Ras-Like Protein in Neurons)
Ras superfamily small GTP (guanosine triphosphate)-binding proteins function as molecular switches, responding to extra- and intracellular stimuli to control the activity of diverse signaling cascades. To date, over 150 different small GTPases have been identified and are classified into six distinct subfamilies – Ras (Rat sarcoma), Rho (Ras homolog gene family), Rab (Ras-related GTP- binding protein), ARF (ADP- ribosylation factor), Ran (Ras-related nuclear protein), and RGK (Rad/Gem/Kir family) – based upon both sequence homology and the regulation of common cellular functions (Colicelli 2004). Rin (Ras-like protein in neurons), along with Rit (Ras-like protein in many tissues) and Drosophila Ric (Ras-related protein which interacted with calmodulin), comprise the Rit subfamily of Ras-related small GTPases (Lee et al. 1996). Rin is expressed exclusively within neurons, including RGCs (retinal ganglion cells)...
This work was supported by Public Health Service grant NS045103 from the National Institute of Neurological Disorders and Stroke and 14-1 from the Kentucky Spinal Cord and Head Injury Research Trust.
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