Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Niharika SwainEmail author
  • Rashmi Maruti Hosalkar
  • Samapika Routray
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_102003


Historical Background

Keratinocytes undergo progressive terminal differentiation to form a stratified squamous epithelium. During the process of keratinization, certain numbers of genes are expressed in suprabasal layer which include a class of genes whose products are cross-linked through action of transglutamase reaction, thus helping in the formation of upper cornified strata. Of the number of proteins said to play a significant role as precursor in the formation of this strata, involucrin (IVL) is one (Eckert et al. 1993). The term “involucrin” is derived from Latin word “involucrum” meaning envelope and was first observed in 1979 in crude extracts of cultured keratinocyctes (Rice and Green 1979). Studies have suggested IVL to assume a rod like shape having glutamate and glutamine residues which promote and serve as major glutamyl donors in transglutaminase catalyzed cross-linking reactions (Eckert et al. 1993).

Gene Transcription and Structure

IVL gene is...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Niharika Swain
    • 1
    Email author
  • Rashmi Maruti Hosalkar
    • 2
    • 4
  • Samapika Routray
    • 3
  1. 1.MGM Dental College and HospitalNavi MumbaiIndia
  2. 2.Indian Association of Oral and Maxillofacial PathologistsMumbaiIndia
  3. 3.Department of Dental SurgeryAll India Institute of Medical SciencesBhubaneswarIndia
  4. 4.Maharashtra State Dental CouncilMumbai, MaharashtraIndia