Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Thymic Stromal Lymphopoietin (TSLP)

  • Jianguang Du
  • Baohua Zhou
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101973

Historical Background

Thymic stromal lymphopoietin (TSLP) was initially identified in conditioned medium from a murine thymic stromal cell line Z210R.1 as a cytokine that supports B cell development (Friend et al. 1994). It promotes the development of B220+/IgM+ immature B cells from cultured fetal liver cells and supports the long-term growth of a B cell line NAG8/7 in vitro. TSLP is a paralog of IL-7 and can substitute for IL-7 in the B cell development in vitro (Ray et al. 1996). In 2000, TSLP was found to signal through a heterodimeric receptor consisting of TSLP receptor (TSLPR) and IL-7 receptor alpha chain (IL-7Rα) (Pandey et al. 2000; Park et al. 2000). Human TSLP was cloned and characterized in 2001 although it shows only 43% amino acid sequence identity to murine TSLP (Quentmeier et al. 2001). In vivo studies with mouse model and in vitro studies showed that TSLP promotes Th2 differentiation and plays a pivotal role in the development and progression of allergic diseases.

TSLP...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PediatricsWells Center for Pediatric ResearchIndianapolisUSA
  2. 2.Department of Microbiology and ImmunologyIndiana University School of MedicineIndianapolisUSA