Sox2 (SRY-Box 2)
The sex-determining region Y (SRY/Sry) gene, which is a mammalian male-specifying factor on the Y chromosome, was first defined in 1990. Since its discovery, more than 20 different Sry-related genes that have high-mobility group (HMG) box sequences similar to Sry have been cloned, and they form the conserved Sry-related HMG box (SOX) gene family. These genes are classified into subgroups based on the HMG box domain structure and other protein characteristics. The members of the SoxB1 group gene family, called Sox1, Sox2, and Sox3, were found to exhibit highly tissue-specific expression during mouse embryogenesis (Bowles et al. 2000). They show similar expression patterns in embryos, and are functionally redundant, with more than 80% amino acid sequence similarity. Sox2 is indispensable during the development of a wide range of species. It targets several...