Historical Background
Deubiquitinating enzymes (DUBs) are proteases which specifically hydrolyze the isopeptide bond between ubiquitin and target proteins in ubiquitin-protein conjugates or between ubiquitin molecules in ubiquitin chains. Ubiquitin-specific protease 8 (USP8), also known as ubiquitin isopeptidase Y (UBPY), was originally identified as a DUB which is upregulated in proliferating cells and promotes the entry of cells into the S-phase of the cell cycle (Naviglio et al. 1998). Subsequent studies, however, have accumulated evidence that this DUB plays a major role in regulating the lysosomal traffic/degradation of plasma membrane proteins upon endocytosis from the cell surface.
Downregulation of Growth Factor Receptors
Sustained signaling from ligand-activated growth factor receptors results in overproliferation of cells and tumorigenesis. To avoid such dangerous incidences, cells internalize...
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Komada, M., Reincke, M., Theodoropoulou, M. (2018). USP8 (Ubiquitin-Specific Protease 8). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101955
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101955
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