Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Tristetraprolin (ZFP36) and TIS11B (ZFP36-L1)

  • Nadia CherradiEmail author
  • Jean-Jacques Feige
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101947


Historical Background

The characterization of the tristetraprolin (TTP) family of RNA-binding proteins started in the early 1990s when Harvey Herschmann first cloned an immediate-early response gene induced by the carcinogenic phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) that he named TIS-11, standing for TPA-induced sequence 11 (Varnum et al. 1989). This and concurrent teams rapidly established...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institut National de la Santé et de la Recherche Médicale Unité 1036GrenobleFrance
  2. 2.CEA, Biosciences and Biotechnology Institute of Grenoble, Laboratory Biology of Cancer and InfectionGrenobleFrance
  3. 3.University Grenoble-AlpesGrenobleFrance