Zinc Finger E-Box-Binding Homeobox 2
Zinc finger E-box-binding homeobox 2 (ZEB2) is a zinc finger and homeodomain transcription factor. ZEB2 was identified as a protein binding to the MH2 domain of different Smad proteins involved in BMP- and TGF-ß pathways (Verschueren et al. 1999). Initial studies correlating ZEB2 and E-cadherin downregulation in carcinomas were followed by a significant amount of research linking ZEB2 and epithelial-to-mesenchymal transition (EMT) during tumor progression (Comijn et al. 2001). Together with its paralog ZEB1, ZEB2 belongs to the Zeb family of transcription factors characterized by two zinc finger clusters separated by a homeodomain. During evolution, the duplication of the ancestral ZEB gene and diversification of ZEB2 from ZEB1 coincide with the onset of neural crest development and specification.