Transient Receptor Potential Cation Channel Subfamily A Member 1 (TRPA1)
Historical Background and Structure
The transient receptor potential ankyrin-1 (TRPA1) is the only member of TRPA channel subfamily in mammals. Initially identified in human lung fibroblasts (Jaquemar et al. 1999), as an ankyrin-like protein with transmembrane domains protein 1 (ANKTM1), it was successively recognized as a TRP channel for its homology with several members of the same superfamily (Story et al. 2003). TRPA1 that has been cloned in invertebrates, such as Caenorhabditis elegans and fruit fly, and in a variety of species, including zebrafish, chicken, mouse, rat, dog, and humans (Nilius and Szallasi 2014), is a protein of about 1100 amino acids (120–130 kDa), although shorter splice variants have also been reported. The human trpa1gene is in chromosome 8q13 and consists of 27 exons and spans 55,701 base pairs. Like other...