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Encyclopedia of Signaling Molecules pp 5779–5786Cite as

Tumor Protein D52 (TPD52)

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Synonyms

CRHSP-28 (rat); CSPP28 (rabbit); hD52 (human); mD52 (mouse); N8 (human); PC-1 (human); PrLZ (human); R10 (quail); Tpd52 (mouse)

Historical Background

Mammalian TPD52 sequences were first described in the mid-1990s, through a number of independent reports and experimental approaches. Publications from 1995 to 1996 identified TPD52 sequences through the detection of increased TPD52 transcript levels in human cancer tissue or cell lines, relative to nonmalignant controls. Orthologous rat, rabbit, or quail transcripts were identified as either encoding proteins that are phosphorylated in response to raised intracellular calcium levels or as a retroviral target gene, respectively. Early reports also identified paralogous human and mouse transcript sequences, and these reports, combined with genome sequencing, demonstrated that TPD52 is one gene within a four-member gene family (reviewed by Boutros et al. 2004; Byrne et al. 2014). While TPD52-like protein sequences are conserved...

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References

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Author information

Authors and Affiliations

  1. Molecular Oncology Laboratory, Children’s Cancer Research Unit, Kids Research Institute, The Children‘s Hospital at Westmead, Locked Bag 4001, 2145, Westmead, NSW, Australia

    Yuyan Chen & Jennifer A. Byrne

Authors
  1. Yuyan Chen
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  2. Jennifer A. Byrne
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Corresponding author

Correspondence to Jennifer A. Byrne .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Chen, Y., Byrne, J.A. (2018). Tumor Protein D52 (TPD52). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101930

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