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Task

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Encyclopedia of Signaling Molecules

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Synonyms

TASK1: KCNK3, K2p3.1, OAT1, PPH4, TASK-1, TBAK1, Potassium two-pore-domain channel subfamily K member 3; TASK3: KCNK9, K2p9.1, KT3.2, TASK-3, Potassium two-pore-domain channel subfamily K member 9

Historical Background

Based on the structural features, K+ channels are classified into the voltage-gated K+ channels, Ca2+-dependent K+ channels, and leak K+ (two-pore-domain K+) channels (Fig. 1). The voltage-gated K+ channels and Ca2+-dependent K+ channels form tetramers, with each subunit containing six or seven transmembrane domains and one pore domain while leak K+ (two-pore-domain K+) channels form dimers, with each subunit containing four transmembrane domains and two pore domains (Goldstein et al. 2001; Bayliss et al. 2003). In excitable cells, a negative membrane potential is critical for electrical signaling, and it has long been considered that this key mechanism is largely mediated by leak K+ currents (Goldman 1943). However, the molecular basis for characterizing...

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Authors and Affiliations

  1. Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, 1-8, Yamadaoka, 565-0871, Suita, Japan

    Hiroki Toyoda

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  1. Hiroki Toyoda
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Correspondence to Hiroki Toyoda .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Toyoda, H. (2018). Task. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101910

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