Synonyms
PAR1:CF2R; Coagulation factor II thrombin receptor; Coagulation factor II (thrombin) receptor; HTR; Proteinase-activated receptor 1; PAR1; PAR-1; Thrombin receptor; TR
PAR2:F2RL1; F2R-like trypsin receptor 1; GPR11; Proteinase-activated receptor 2; PAR2; PAR-2
PAR3:Coagulation factor II thrombin receptor-like 2; Coagulation factor II (thrombin) receptor-like 2; F2RL2; Proteinase-activated receptor 3; PAR3; PAR-3; Thrombin receptor-like 2
PAR4:Coagulation factor II (thrombin) receptor-like 3; Coagulation factor II receptor-like 3; F2RL3; F2R-like thrombin/trypsin receptor 3; PAR4; PAR-4; Proteinase-activated receptor 4; Thrombin receptor-like 3
Historical Background
Since about 50 years, serine proteinases like chymotrypsin and pepsin have been known to cause hormone-like effects in target tissues. In addition, in the 1970, thrombin and trypsin have been demonstrated to stimulate mitogenesis by acting at the cell surface. However, the mechanisms responsible for the growth...
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Kaufmann, R., Settmacher, U., Ungefroren, H. (2018). Proteinase-Activated Receptors (PARs). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101885
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