Proteinase-Activated Receptors (PARs)
PAR4: Coagulation factor II (thrombin) receptor-like 3; Coagulation factor II receptor-like 3; F2RL3; F2R-like thrombin/trypsin receptor 3; PAR4; PAR-4; Proteinase-activated receptor 4; Thrombin receptor-like 3
Since about 50 years, serine proteinases like chymotrypsin and pepsin have been known to cause hormone-like effects in target tissues. In addition, in the 1970, thrombin and trypsin have been demonstrated to stimulate mitogenesis by acting at the cell surface. However, the mechanisms...
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