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Encyclopedia of Signaling Molecules pp 5741–5749Cite as

TRPM4

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Synonyms

HTRPM4; LTrpC-4; PFHB1B; Transient receptor potential cation channel subfamily M member 4; TRPM4B

Historical Background

Transient receptor potential, subfamily M(melastatin-related), member 4 (TRPM4) gene encodes a channel protein responsible for a Ca2+-activated nonselective cationic (NSCCa) current. Electrophysiological signatures of such currents are known since the beginning of patch clamp single-channel recordings. They were observed in a wide variety of tissues in the 1980s to 2000s, including epithelia, secretory tissues, or excitable cells (neurons and myocytes) (see Guinamard et al. 2011for review). However, these currents remained orphaned until the cloning of the TRP gene family at the end of the 1990s. Among these, TRPM1 (melastatin) has been cloned in 1998 and opened the way for the new subfamily TRPM which is composed of eight members (1–8). Based on homology sequence screening of a cDNA library, Xu et al. identified a first sequence of the TRPM4 gene in human...

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References

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Author information

Authors and Affiliations

  1. Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardique, Normandie Univ, UNICAEN, 14000, Caen, France

    Romain Guinamard, Christophe Simard & Laurent Sallé

Authors
  1. Romain Guinamard
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  2. Christophe Simard
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  3. Laurent Sallé
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Corresponding author

Correspondence to Romain Guinamard .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Guinamard, R., Simard, C., Sallé, L. (2018). TRPM4. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101882

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