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Encyclopedia of Signaling Molecules pp 4994–5002Cite as

SLC24A Family (K+-Dependent Na+-Ca2+ Exchanger, NCKX)

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Synonyms

K+-dependent Na+/Ca2+ exchanger; Na+/Ca2+-K+ exchanger; NCKX; Potassium-dependent sodium/calcium exchanger; Sodium/calcium-potassium exchanger; Solute carrier 24A gene family

Historical Background

Tightly controlled changes in cytosolic free Ca2+ concentration are widely involved in cell signaling in most tissues of our body. Free Ca2+ concentration is increased through the activation of a wide range of surface or intracellular Ca2+ channels and is returned to resting values through the action of ATP-driven Ca2+ pumps located in the plasma membrane and endoplasmic reticulum as well as Na+/Ca2+ exchangers located on the plasma membrane. By the mid 1980s, it had been established that the surface membrane of the outer segments of retinal rod photoreceptors (ROS) contained a potent Na+-Ca2+ exchange mechanism (Schnetkamp 1980; Yau and Nakatani 1984), and, in 1988, the Na+-Ca2+ exchanger protein was purified from bovine ROS as a 220 kDa glycoprotein (Cook and Kaupp 1988). In 1989,...

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada

    Ali H. Jalloul, Robert T. Szerencsei, Tatiana P. Rogasevskaia & Paul P. M. Schnetkamp

  2. Department of Biology, Mount Royal University, 4825 Mt Royal Gate SW, Calgary, AB, T3E 6K6, Canada

    Tatiana P. Rogasevskaia

Authors
  1. Ali H. Jalloul
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  2. Robert T. Szerencsei
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  3. Tatiana P. Rogasevskaia
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  4. Paul P. M. Schnetkamp
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Corresponding author

Correspondence to Paul P. M. Schnetkamp .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Jalloul, A.H., Szerencsei, R.T., Rogasevskaia, T.P., Schnetkamp, P.P.M. (2018). SLC24A Family (K+-Dependent Na+-Ca2+ Exchanger, NCKX). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101860

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