Retinol-Binding Protein 4 (RBP4)
Retinol-binding protein 4 (RBP4), previously known as RBP, is a career of retinol in plasma that transport retinol from liver to peripheries. This protein mainly produced by liver and partly from adipose tissue RBP4 is encoded by the Rbp4 gene, localized in the chromosome 10q23-q24 including 8 exons. The lack of RBP4 leads to vitamin A deficiency in Rbp4 knockout mice. RBP4 that is not bound to retinol is called as Apo-RBP4, whereas retinol-bound RBP4 (holo- RBP4) associates with transthyretin (TTR) in plasma in order to stop RBP to be lost during kidney filtration. Stimulated by retinoic acid 6 (STRA6) is the cell surface receptor for RBP4. For years RBP4 was known just as a vitamin A career and a negative phase marker of acute inflammation; however, recent studies provided a novel insight to RBP4 and its role in inflammation and obesity-related complications including...
- Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase-and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012;32(10):2010–9.PubMedPubMedCentralCrossRefGoogle Scholar
- Soprano D, Blaner W. Plasma retinol-binding protein. In: Sporn MB, Roberts AB, Goodman DS, editors. The retinoids: biology, chemistry and medicine. New York: Raven Press; 1994.Google Scholar