Peroxisome Proliferator-Activated Receptor (PPAR)
PPARs were initially discovered while delineating mechanisms that induce peroxisome proliferation in rodents, hence the name of peroxisome proliferator-activated receptor. PPARα was the first identified isoform cloned from a mouse liver complementary DNA library in 1990 from researchers working on the mechanisms implicated in the promoting action of a variety of chemicals on peroxisomal proliferation in the rodent liver (Issemann and Green 1990). The identified protein presented a high degree of similarity with several members of the nuclear hormone receptor superfamily and was highly expressed in liver, kidney, heart, and brown adipose tissue. Τhe other two PPAR isoforms called PPARβ/δ and PPARγ were later identified in Xenopus laevis (Dreyer et al. 1992), human (Greene et al. 1995), and mouse (Chen et al. 1993).
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