Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Phosphatidylinositol 4-Kinase Type II Alpha

  • Yassmeen Radif
  • Mark G. Waugh
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101785

Synonyms

 EC 2.7.1.67;  Phosphatidylinositol 4-Kinase Type IIα;  PI4K2A;  PI4KIIα;  Type II Phosphatidylinositol 4-Kinase α

Historical Background

Phosphatidylinositol 4-kinase type II α, also commonly referred to as PI4K2A or PI4KIIα, is a 54 kDa lipid kinase that catalyzes the phosphorylation of the membrane lipid phosphatidylinositol on the D4 position of its inositol headgroup to produce phosphatidylinositol 4-phosphate (PI4P). There are three other phosphatidylinositol 4-kinases expressed in most mammalian cells, PI4KB, PI4KA, and PI4KB. PI4K2A is highly homologous to the PI4KB isozyme, and together they are classified as the type II phosphatidylinositol 4-kinases (reviewed in Boura and Nencka 2015; Clayton et al. 2013). The type II phosphatidylinositol kinases differ from the type III PI4KA and PI4KB isozymes in that they are insensitive to the phosphoinositide 3-kinase inhibitors wortmannin and LY-294002, but are inhibited by low micromolar concentrations of adenosine....

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Lipid and Membrane Biology Group, Institute for Liver and Digestive Health, Division of MedicineUniversity College LondonLondonUK