Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Complement Factor H (CFH)

  • Eduardo Lamas-Basulto
  • Anne M. Dersch
  • Claudio CortesEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101784


Historical Background

The complement system, the major noncellular component of the innate immune system, is composed of three different pathways: the classical (CP), the lectin (LP), and the alternative pathway (AP). These pathways participate in several processes, including tagging pathogens for phagocytosis, directing destruction of microorganisms, promoting inflammation, contributing to immune complex regulation, and linking the innate and adaptive immune systems. The complement system has two fundamental properties: discriminates self (e.g., host cells) from nonself (e.g., pathogens) and regulates itself to prevent unwanted damage. These properties, common to all arms of the immune system, are required for proper protection and...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Eduardo Lamas-Basulto
    • 1
  • Anne M. Dersch
    • 1
  • Claudio Cortes
    • 1
    Email author
  1. 1.Oakland University William Beaumont School of MedicineRochesterUSA