Phosphatidylethanolamine-binding protein 1 (PEBP-1) was first isolated as a cytosolic, 23 kDa protein from bovine brain and was also found in soluble extracts from human platelets and rodent brains (Bernier and Jolles 1984). A series of studies over the next decade led to its identification as the precursor for hippocampal cholinergic neurostimulating peptide (HCNP), an acetylated eleven amino acid long peptide conserved in the rat, human, and bovine genome (Tohdoh et al. 1995). Although, it was originally named for its binding affinity for the phospholipid phosphatidylethanolamine, a breakthrough report characterized PEBP-1 as a Raf-1 kinase binding protein with the ability to inhibit the mitogen-activated protein kinase (MAPK) pathway;...
- Bernier I, Jolles P. Purification and characterization of a basic 23 kDa cytosolic protein from bovine brain. Biochim Biophys Acta (BBA)/Protein Struct Mol. 1984;790(2):174–81.Google Scholar