Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Microtubule Affinity Regulating Kinase-4

  • Neha Sami
  • Vijay Kumar
  • Md. Imtaiyaz HassanEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101744


Historical Background

Microtubules (MTs) are regulated by a large number of proteins and factors. One of the classes of protein that act as a regulator of microtubules are microtubule-associated proteins (MAPs) like tau, MAP2, and MAP4 (Mandelkow and Mandelkow 1995). MAPs are widely found in the brain of vertebrates and have been studied in detail (Illenberger et al. 1996). The protein kinases like MAP/microtubule-affinity regulating kinases (MARK) phosphorylate these MAPs and regulate their activity (Drewes et al. 1997).

Microtubule-affinity regulating kinase 4 (MARK4) was first discovered in the brain of Alzheimer’s disease (AD) patients. Overexpressed MARK4 phosphorylates tau on Ser262 in the microtubule-binding domain,...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Centre for Interdisciplinary Research in Basic SciencesJamia Millia IslamiaNew DelhiIndia