Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

OSBP and OSBPL1–11/ORP1–11

  • Vesa M. OlkkonenEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101732


Historical Background

During early studies on the regulation of cellular cholesterol homeostasis, oxysterols such as 25-hydroxycholesterol (25-OHC) were found to potently reduce the activity of HMGCoA reductase, a rate-limiting enzyme in cholesterol biosynthesis. These findings motivated search for proteins mediating the effects of oxysterols on cholesterol homeostatic machinery, resulting in the isolation of protein fractions with oxysterol-binding activity. Taylor, Kandutsch, and coworkers identified in the 1980s a cytosolic oxysterol-binding protein (OSBP), which was purified (Taylor et al. 1984; Dawson et al. 1989), and cDNAs were cloned from different species....

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Minerva Foundation Institute for Medical ResearchHelsinkiFinland