N-Lysine Methyltransferase SMYD
Reference work entry
SMYD proteins are a family of histone and protein lysine methyltransferases containing a SET domain interrupted by a MYND zinc finger motif (Spellmon et al. 2015) (Fig. 1). The SET domain is evolutionally conserved in N-lysine methyltransferases and responsible for the methyltransferase activity (Sirinupong et al. 2010). The MNYD domain is a protein–protein interaction module involved in transcriptional cofactor recruitment (Spellmon et al. 2015). The SMYD family achieves the methyltransferase activity by adding methyl groups to target lysine residues using S-adenosylmethionine (AdoMet) as a donor substrate (Fig. 1). Recent studies show the SMYD protein family to be involved in cancer proliferation, epigenetic transcription regulation, the immune system,...
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