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Encyclopedia of Signaling Molecules pp 2939–2946Cite as

MAP/Microtubule Affinity-Regulating Kinase

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Synonyms

MARK1: EMK3, hPAR-1c, KIAA1477; MARK2: EMK1, hPAR-1b; MARK3: EMK3, hPAR-1a, C-TAK1, KP78; MARK4: MARKL1, hPAR-1d, KIAA1860

Historical Background

Microtubule-associated protein (MAP)/microtubule affinity-regulating kinase [MARK] was first identified for its role in phosphorylating tau, a MAP implicated in Alzheimer’s disease [AD] (Drewes et al. 1995). Following this discovery, four MARK isoforms were identified in humans and rodents, all of which phosphorylate tau, MAP2, and MAP4 (Drewes et al. 1995; Illenberger et al. 1996; Drewes 2004). Phosphorylation of MAPs causes them to dissociate from microtubules [MTs] leading to MT destabilization (Drewes et al. 1997, 1998). Tau has been the subject of intensive studies because its phosphorylation is elevated in the AD brain. Since MARK phosphorylates tau, it is a candidate of prime interest as a possible therapeutic target in treating AD and other brain disorders (Drewes 2004; Naz et al. 2013). MARK has also been found to be...

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Acknowledgments

This work was supported by grants from the National Institutes of Health, NICHD, R01 HD056034 to C.Y.C., and U54 HD029990 Project 5 to C.Y.C.

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Authors and Affiliations

  1. The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY, 10065, USA

    Elizabeth Tang & C. Yan Cheng

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  1. Elizabeth Tang
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  2. C. Yan Cheng
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Correspondence to C. Yan Cheng .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Tang, E., Cheng, C.Y. (2018). MAP/Microtubule Affinity-Regulating Kinase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101717

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