Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MAP/Microtubule Affinity-Regulating Kinase

  • Elizabeth Tang
  • C. Yan Cheng
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101717

Synonyms

Historical Background

Microtubule-associated protein (MAP)/microtubule affinity-regulating kinase [MARK] was first identified for its role in phosphorylating tau, a MAP implicated in Alzheimer’s disease [AD] (Drewes et al. 1995). Following this discovery, four MARK isoforms were identified in humans and rodents, all of which phosphorylate tau, MAP2, and MAP4 (Drewes et al. 1995; Illenberger et al. 1996; Drewes 2004). Phosphorylation of MAPs causes them to dissociate from microtubules [MTs] leading to MT destabilization (Drewes et al. 1997, 1998). Tau has been the subject of intensive studies because its phosphorylation is elevated in the AD brain. Since MARK phosphorylates tau, it is a candidate of prime interest as a possible therapeutic target in treating AD and other brain disorders (Drewes 2004; Naz et al. 2013). MARK has also been found to be...

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Notes

Acknowledgments

This work was supported by grants from the National Institutes of Health, NICHD, R01 HD056034 to C.Y.C., and U54 HD029990 Project 5 to C.Y.C.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population CouncilNew YorkUSA