Membrane-associated guanylate kinases (MAGUKs) are a family of proteins generally involved in scaffolding. Functions for these proteins have been described in diverse cellular processes such as epithelial polarity and maintenance, cell-cell communication, synapse physiology, cell polarity, and signal transduction (Oliva et al. 2012). The protein family is characterized by the presence of a guanylate kinase (GK) domain, homologous to the bacterial guanylate kinase enzyme involved in the transfer of a phosphate group from ATP to GMP, essential in GTP synthesis (Li and Yan 1996; Zhu et al. 2012). However, in the MAGUK family, this domain is enzymatically inactive and instead mediates protein-protein interactions.
The founder members of the MAGUK family are the postsynaptic density proteins of 95 KDa (PSD95), Zonula Occludens 1 (ZO1) and the DrosophilaDiscs Large (DLG). They share a similar structure with PDZ...
- Hill WD, Davies G, van de Lagemaat LN, Christoforou A, Marioni RE, Fernandes CPD, et al. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins. Transl Psychiatry. 2013;4(1):e341–8.CrossRefGoogle Scholar