Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Intercellular Adhesion Molecule 1

  • Srirupa Mukhopadhyay
  • Tejinder Pal Khaket
  • Tapan Kumar MukherjeeEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101706


Historical Background

Intercellular adhesion molecule 1 (ICAM-1; CD54) is a cell adhesion molecule of immunoglobulin (Ig) superfamily expressed by several cell types including leukocytes and endothelial cells with critical involvement in arrest and transmigration of leukocytes from blood vessels into tissues. In 1986, Timothy Springer and his group first described the tissue distribution of ICAM-1 into both hematopoietic cells, (viz. tissue macrophages, mitogen-stimulated T lymphocyte, germinal center den dendritic cells in tonsils, lymph nodes and Peyers pathches) and non-hematopoietic cells, (viz. vascular endothelial cells, thymic epithelial cellscertain other types of epithelial cells and fibroblasts) (Rothlein et al. 1986). In later years, further studies demonstrated that purified ICAM-1 protein acts as a natural ligand for the cell surface lymphocyte function-associated antigen 1...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Srirupa Mukhopadhyay
    • 1
  • Tejinder Pal Khaket
    • 2
  • Tapan Kumar Mukherjee
    • 2
    Email author
  1. 1.Department of Immunopathology, Post Graduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of BiotechnologyMaharishi Markandeshwar UniversityMullanaIndia