Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Natalie Foot
  • Sharad KumarEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101705


Historical Background

Nedd4 family-interacting protein 1 (Ndfip1) was first identified in a far-western screen searching for proteins that interact with the WW domains of the Nedd4 ubiquitin ligase (Jolliffe et al. 2000). It was initially named Nedd4 WW domain-binding protein 5 (N4WBP5). Following this discovery, a closely related mammalian protein was identified (named N4WBP5A, now called Ndfip2) and further characterized as belonging to a small group of evolutionarily conserved proteins (Harvey et al. 2002), with a single homologue in yeast [Bsd2p (Hettema et al., 2004)] and Drosophila...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Centre for Cancer BiologyUniversity of South AustraliaAdelaideAustralia