Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Ku70 and Ku80

  • Guido KeijzersEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101685


Ku70; Ku69; X-ray repair cross-complementing 6 (XRCC6); Lupus Ku autoantigen protein p70; ATP-dependent DNA helicase 2 subunit 1; X-ray repair complementing defective repair in Chinese hamster cells 6. Ku80; Ku86; X-ray repair cross- complementing 5 (XRCC5); Lupus Ku autoantigen protein p80; X-ray repair complementing defective repair in Chinese ham ster cells 6; ATP-dependent DNA helicase 2 subunit 2. 17 2 subunit 2. Ku70/80 heterodimer; Ku70/80; Ku(p70/p80); ku heterodimer.

Historical Background

The Ku70/80 heterodimer (also named Lupus Ku autoantigen protein p70 and Lupus Ku autoantigen protein p80) was first isolated from sera of systemic lupus erythematosus patients (LSE) (Reeves 1987). LSE is an autoimmune disease, whereby the immune system mistakenly attacks healthy tissue, resulting in red rash, as a response of inflammation. Both the Ku70 and Ku80 subunits were subcloned (Reeves and Sthoeger 1989; Mimori et al. 1990), but the breakthrough occurred with the discovery...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Center for Healthy Aging, Department of Cellular and Molecular MedicineUniversity of CopenhagenCopenhagenDenmark