Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Chengcheng ZhangEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101680


Historical Background

Immunoreceptor tyrosine-based inhibitory motif (ITIM) was first described in 1995. This conserved motif consists of six amino acids (S/I/V/LxYxxI/V/L) located in the cytoplasmic portion of certain transmembrane receptors (Daeron et al. 1995). Proteome-wide analysis identified 109 human ITIM-containing receptors (Staub et al. 2004). Conformational changes induced by ligand binding results in Src kinase-mediated phosphorylation of tyrosine in the ITIM, which in turn leads to the recruitment of SH2 domain-containing phosphatases. The ITIM-containing receptors bind tyrosine phosphatases...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.UT Southwestern Medical CenterDallasUSA