Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Krüppel-Like Factor 4 (KLF4)

  • Tadashi YoshidaEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101673


Historical Background

The Krüppel-like factor (KLF) family is a subclass of zinc-finger containing DNA-binding transcription factors. There are currently 17 known KLF family members in mammals. The unique feature of the KLF family members is the presence of three highly conserved cysteine 2/histidine 2 (C 2H 2)-type zinc fingers at the carboxyl terminus of the protein, while other regions are highly divergent to carry out their individual functions (Fig. 1). KLF4 is one of the most attractive factors in the KLF family members, because it is implicated in multiple important processes including cellular proliferation, differentiation, and the establishment of pluripotency. KLF4 was first identified from a murine NIH/3T3 fibroblast cDNA library (Shields et al. 1996). Because it was expressed most abundantly in the colon, followed by the testis, lung, and small intestine, KLF4 was initially named as...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Apheresis and Dialysis Center, School of MedicineKeio UniversityTokyoJapan