Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Jérôme Boudeau
  • Susanne Schmidt
  • Anne DebantEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101658


Historical Background

Human Trio was identified in the late 1990s in a two-hybrid screen using the cytoplasmic fragment of the transmembrane tyrosine phosphatase LAR as a bait (Debant et al. 1996). The name of Trio came from the observation that Trio comprises three enzymatic domains: two GEF domains predicted to activate Rho GTPases and one serine kinase domain. It was rapidly shown that both GEF domains are active, the GEFD1 activating Rac1/RhoG and the GEFD2 domain acting on RhoA. While the function of Trio was unclear at that time, the first indication of its function came from studies in C. elegans, when it was discovered that UNC-73, a major regulator of axon guidance and cell motility, was the ortholog of mammalian Trio (Steven et al. 1998). Two years later, the Drosophila trio gene was shown by different groups to be essential for axon guidance viathe activation of Rac through its first GEF domain (Bateman and...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Jérôme Boudeau
    • 1
  • Susanne Schmidt
    • 1
  • Anne Debant
    • 1
    Email author
  1. 1.Centre de Recherche en Biologie cellulaire de Montpellier, CRBMCNRS, Univ. MontpellierMontpellier CedexFrance