Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Intercellular Adhesion Molecule-5

  • Sonja Paetau
  • Carl G. GahmbergEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101656


Historical Background

The discovery of ICAM-5 was made by K. Mori and colleagues in 1987. Mice were immunized with the synaptic fractions of olfactory bulb neurons and a series of monoclonal antibodies was generated. One of the antibodies showed immunoreactivity exclusively with the telencephalon (Mori et al. 1987). The target molecule was named telencephalin. Further analysis with this antibody showed a somatodendritic distribution, specific to neuronal membranes. The expression was found to be developmentally regulated.

By affinity chromatography, telencephalin was characterized as a 500 kDa glycoprotein consisting of four monomers. In subsequent studies, the target cDNA was generated and considerable homology to the intercellular adhesion molecule, ICAM, family found (Yoshihara et al. 1994). Telencephalin was included as the fifth and so far the youngest member of the family. Consistent with the nomenclature, it was renamed ICAM-5...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Biosciences, Division of Biochemistry and Biotechnology, Faculty of Biological and Environmental SciencesUniversity of HelsinkiHelsinkiFinland