Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

High Mobility Group Box B1

  • Xuanbin WangEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101643


Historical Background

High mobility group (HMG) chromosomal protein family was first discovered in 1973 (Goodwin and Johns 1973; Goodwin et al. 1973). At that time, the name HMG was defined according to their high electrophoretic mobility in polyacrylamide gels. Then in 1976, α-helix structures of HMGs were identified (Baker et al. 1976; Cary et al. 1976). In 2001, the domains of HMG1 were characterized (Thomas 2001), and at the same year, the HMG Chromosomal Protein Nomenclature Committee recategorized the proteins into three superfamilies: HMGB (formerly known as HMG-1/2), HMGA (formerly known as HMG-14/17), and HMGN (formerly known as HMG-1/Y) (Bustin 2001). Up to date, the functions of HMGB family...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Laboratory of Chinese Herbal Pharmacology, Oncology Center, Renmin HospitalHubei University of MedicineShiyanChina